08/22/2010

Experts find gene variants for stomach, gullet cancer

Aug 23 (Reuters) - Scientists have identified genetic mutations that appear to be associated with both esophageal and stomach cancer in two studies in China, suggesting they may share similar triggers.

This finding adds to the understanding of how these cancers develop and may help in the hunt for cures.

In the first study, Chinese researchers analysed genes of 9,053 patients with esophageal cancer and 2,766 with stomach cancer. The research also included a smaller number of esophageal cancer patients of Uighur-Kazakh descent.

Two mutations -- PLCE1 at location 10q23 and C20orf54 at location 20p13 -- showed up consistently in all these patients, the researchers wrote in a paper published in Nature Genetics on Monday.

"These results show that genetic variations at 10q23 and 20p13 contribute significantly to risk for esophageal cancer and (stomach) cancer in Chinese Han and Uighur-Kazakh populations," wrote the researchers, led by Wang Lidong at the Xinxiang Medical University in China's central Henan province.

China bears roughly half of the world's burden of these two cancers. Stomach cancer, the number-two killer after lung cancer, kills 803,000 people around the world each year, while esophageal cancer kills 400,000.

Read more at REUTERS

Aug 22, 2010 3:53:37 PM | Current Affairs, Medicine, Science

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